Amid myriad peaks, clouds arise; the clear lotus dances in the breeze.

Acidic NIC stood out from 74 papers to win the “Yongshun Cup” Top Ten Outstanding Paper Award!

In June in the South, the summer air is fragrant with lotus blossoms, and all things vie in splendor.

This month 25 Day, No. 35 The Guangdong Animal Husbandry and Veterinary Science and Technology Conference opened ceremoniously in Guangzhou. With the theme “Empowering the Integration of Science, Industry, and Innovation to Drive High-Quality Development,” the conference brought together industry representatives from government authorities, universities and research institutions, leading enterprises, and grassroots organizations to discuss strategies for advancing high-quality development in Guangdong’s animal husbandry sector. Top experts—including Professor Zhao Shuhong, an academician of the Chinese Academy of Engineering and professor at Huazhong Agricultural University; Professor Liao Ming, president of Zhongkai University of Agriculture and Engineering; and Chief Veterinarian Zhai Xinyan of the China Animal Disease Prevention and Control Center—delivered keynote speeches, sharing in-depth insights on cutting-edge technological breakthroughs and the core elements of new‑type productive forces in the livestock and poultry industries. Six specialized forums simultaneously addressed key areas, including scientific and technological innovation in the poultry industry, academic exchanges on pig farming, high‑quality development of waterfowl, animal nutrition and feed, and ruminant livestock science. Delegates from institutions such as South China Agricultural University, Guangdong Academy of Agricultural Sciences, Guangdong Ocean University, Foshan University, Zhongkai University of Agriculture and Engineering, and Guangdong College of Science and Trade, as well as R&D centers of companies including Wens Group, Haida Group, and Yongshun Pharmaceutical, participated in exchanges and discussions. This annual academic event has gathered the industry’s most forward‑looking ideas and explorations, guiding efforts to harness technology to foster new‑type productive forces in the evolving landscape.

In this year’s “Yongshun Cup” outstanding paper selection, researchers from South China Agricultural University, the Provincial Academy of Agricultural Sciences, Ocean University, Foshan University, Zhongkai University of Agriculture and Engineering, as well as R&D centers and research institutes of various feed and livestock groups, actively submitted their papers. Guangdong nuacid Innovation Center ( NIC Paper submitted by the team "Monoglyceride of lauric acid in goose astrovirus ( GAstV ) Evaluation of Antiviral Efficacy in Infection Models》 From 74 Among the submitted papers, it stood out and won the Top Ten Outstanding Paper Award, marking the only corporate R&D center to receive this honor for two consecutive years!

Last year, acid energy NIC The team’s project, “Antioxidant Effects of a Combination of Daidzein and Ampelopsis Flavonoids on Ovarian Granulosa Cells in Laying Hens and Its Impact on Production Performance During the Late Laying Phase,” was shortlisted among the top ten. Focusing on identifying gaps in the mechanisms underlying enhanced egg production during the peak laying period in high-yielding hens, the study elucidates the molecular mechanisms that sustain this peak. This research continues to address key industry challenges and hot topics, including gout in geese—a highly lethal disease characterized by urate salt deposition in internal organs, resulting from a combination of nutritional and viral factors—and collaborates with provincial authorities. Institute of Animal Health, Chinese Academy of Agricultural Sciences Researcher Sun Minhua’s team, specializing in waterfowl diseases, has jointly conducted research on medium-chain fatty acids such as lauric acid monoglyceride (trade name Thai acid ) Antiviral efficacy evaluation study in a goose astrovirus infection model.

Since 2015 Since [year], a highly lethal disease characterized by urate deposition in the viscera of goslings has repeatedly broken out in goose-raising regions across China. Affected goslings exhibit joint swelling and difficulty standing; necropsy reveals abundant urate crystals on the surfaces of visceral organs such as the liver and kidneys, as well as within joint cavities, with mortality rates reaching as high as [percentage]. 20% to 50% . Research has confirmed that goose astrovirus 2 Type ( GAstV-2 ) is the main causative agent of this disease. Goose infection GAstV   Effects on xanthine oxidase in the liver ( Xanthine oxidase, XOD ) and adenosine deaminase ( Adenosine deaminase, ADA ) Increased activity, renal multidrug resistance-associated protein 4 ( MRP4 ) of mRNA Transcription levels are significantly reduced. These studies indicate that GAstV Infection affects the expression or activity of enzymes in the liver involved in uric acid production and impairs renal excretory function, leading to hyperuricemia and the development of gout. Furthermore GAstV It can induce apoptosis in lymphocytes and macrophages, potentially causing immunosuppression, increasing the risk of mixed infections, and exacerbating gout-like symptoms in geese. However, to date, no commercially available vaccines or drugs exist for the effective control of this disease.

Researcher Sun Minhua’s team has long been deeply engaged in the study of the etiology and control technologies for goose astrovirus disease, accumulating a solid theoretical and practical foundation in virus isolation and identification, pathogenic mechanisms, and prevention and control strategies. Acidic energy NIC Under the leadership of Researcher Hu Youjun, the team has been developing functional fatty acid (medium-chain fatty acid) additives and reducing viral loads. PEDV 、 PRRSV has achieved remarkable results; this joint research effort will combine the Academy of Agricultural Sciences’ extensive expertise in virus model construction and pathogenic mechanisms with NIC The joint research on medium-chain fatty acids is organically integrated to jointly explore the physiological effects of lauric acid monoglyceride and other compounds on goslings infected with goose astrovirus.

Selection for the experiment 107 only 1 Day-old Magang goslings, rigorously selected to ensure GAstV-1/2 After testing negative for both nucleic acid and antibodies, the subjects were randomly assigned to a control group, an infection challenge group, and an antibody treatment group, 0.1%GML group and 0.15% GML Group. The challenge group received a leg injection. GAstV-2 GDYJ2210 viral stock solution, GML Group daily feeding 0.1%-0.15% Concentration GML powdered pills, trial period 16 Heavens.

The results show ， 0.15% GML The group excels across multiple dimensions:

• Significantly reduced renal viral load: at day post-challenge 7 Heavens, 0.15% GML Renal viral load in the group was significantly lower than that in the challenge group;

• Improving uric acid metabolism: 0.15% GML The serum uric acid level in the group was significantly lower than that in the infected group and 0.1% GML group;

• Mitigation of liver and kidney injury: Histopathological scoring showed that, 0.15% GML The group’s kidney score was significantly lower than that of the challenged group;

• Improve growth performance: On day 🛏️ after challenge 16 Heaven, antibody treatment group, 0.1%GML group and 0.15% GML The group mean body weights were significantly higher than those of the challenged group.

Figure 1: Effect of taurine on the production performance of Ma’ang geese infected with GAstV-2 virus

Figure 2  Tartaric acid against infection GAstV-2 Effects of the virus on serum uric acid and xanthine oxidase in Ma’ang geese

Figure 3. Effect of taurine on viral load in the liver and kidneys of Ma’ang geese infected with GAstV-2 virus