Reduction-Substitution-Antagonism Plan: Acid Power Strives to Lead, Decisive Battle of the 14th Five-Year Plan Amidst Turbulent Times

Guangdong nuacid has been honored with the “Swine Reduction, Replacement, and Resistance” award. / National Award for Outstanding Solutions in Antibiotic-Free Farming

National Swine Technology Innovation Center It is the first national technology innovation center in the agricultural sector approved by the Ministry of Science and Technology. As a national platform, how can we further align with the strategic national priorities of the swine industry and meat food safety, taking the resolution of critical technological bottlenecks and ceiling technologies in swine production as our core mission, and adopting a collaborative approach to enhance the core competitiveness of the swine industry?

In “ 14th Five-Year Plan ” In this final year, how can we further develop new‑type productive forces in the swine industry to reduce and replace antibiotics in feed and farming, minimize antibiotic residues and resistance, and ensure food and medication safety? How can we improve technologies for reducing and eliminating antibiotics in swine production, enhance the quality of pork products, foster the greater health industry, and promote the sustainable development of the swine sector? National Swine Technology Innovation Center In collaboration with the National Engineering Research Center for Joint Biological Feed Development, the Key Laboratory of the Ministry of Agriculture and Rural Affairs, and other institutions, a number of initiatives to reduce and replace antibiotics in swine production were solicited from across society. / The technical requirements and solutions for antibiotic-free farming, after rigorous selection by experts, saw several feed-based alternatives to antibiotics and strategies for reducing antibiotic use—submitted by institutions including Southwest University and Guangdong Sanneng—stand out. These were then subjected to final expert review and, on… 2025 year 7 month 11 A meeting on reducing and replacing swine and enhancing resistance was held in Chengdu. / Expert Symposium on Solutions for Antibiotic-Free Livestock Farming.

Researcher Hu Youjun, Chief Scientist of Guangdong nuacid Biotechnology Co., Ltd., presented a report to experts at the National Swine Technology Innovation Center. “ An alternative to antibiotics: acidifying agents for intestinal bacteriostasis and reduction of viral load ” It highlights four core areas: the importance of acidifying agents following the ban on antibiotics, the selection and precise application of intestinal bacteriostatic acids, the selection and application of acidifying agents to reduce viral loads, and research and development along with initial demonstration applications.

Following rigorous expert review and presentations of other projects, the conference officially awarded first-, second-, and third-place prizes, totaling 5 Item. Proposed jointly by Guangdong nuacid Company together with Sichuan Agricultural University, Jiangxi Agricultural University, Foshan University, and other universities. “ An alternative to antibiotics: acidifying agents for intestinal bacteriostasis and reduction of viral load ”  It emerged as a frontrunner, tying for first place with the proposal submitted by Southwest University, and was officially awarded. “ Reducing replacement and resistance in swine / An excellent solution for antibiotic-free farming ” The grand prize—winning this prestigious honor, The plan has been included in the technical library of the National Swine Technology Innovation Center. This award is not only a high recognition of nuacid Biotechnology’s strength but also an acknowledgment of its achievements in “ Reduce resistance / Antibiotic-free ” Recognition of innovative achievements in the aquaculture sector. The following outlines the main contents of the report.

2020 In [year], China imposed a comprehensive ban on the production and use of growth-promoting drug feed additives, marking the official entry of the livestock industry into... “ The Era of Antibiotic Prohibition ” . High doses and the use of multiple types of traditional antibiotics were once the primary means of inhibiting bacteria and viruses, improving digestion, and controlling diarrhea, but the resulting food safety residues and antibiotic resistance issues cannot be ignored. nuacid Bio keenly identifies industry pain points and proposes “ Considering Gut Health from the Perspective of Antimicrobial and Antiviral Effects ” Its core concept involves constructing a scientifically sound antibiotic‑replacement strategy through a diversified combination of acidifiers, enzyme preparations, and probiotics. Among these, acidifiers—owing to their broad‑spectrum antibacterial activity, low propensity for resistance development, and ability to protect beneficial microbes—have emerged as one of the key technologies for replacing antibiotics.

Acid can NIC The research focuses on a classic acidifier with a broad antibacterial spectrum, which is gentle on beneficial bacteria and unlikely to induce resistance. —— Benzoic acid. However, conventional benzoic acid has obvious limitations in its applications:

1.  Poor adaptability to the intestinal environment: Benzoic acid in pH=4.2 Only at the time 50% Exists in molecular form (with antibacterial activity), while in the distal intestine pH It is relatively high, resulting in a significant reduction in its antibacterial efficiency.

2. Metabolic side effects: High inclusion levels can impair palatability and reduce feed intake in livestock and poultry, and they may cause fluctuations in blood glucose. After rapid absorption, the compound is metabolized into hippuric acid, which could increase renal workload.

To address these issues, nuacid Bio has innovatively developed an embedded coating formulation process (e.g., “ Love Sour Spirit ®5001/9001/9003” ) Possesses the following technical features :

① Sustained-release technology enables benzoic acid to be continuously released in the intestine. 6 More than an hour, precisely targeting the mid-to-late stages, enhancing antibacterial efficiency. 50%。

② Synergistic enhancement: Added permeabilizing ingredients promote the penetration of benzoic acid molecules through bacterial cell membranes, achieving 1 Kilogram substitution 3 The effect of one kilogram of pure benzoic acid.

③ Safety optimization: The microbead shape is designed to prevent caking, with no irritating odor, improving the working environment.

Empirical results show that, in the weaned piglet trial, 0.1% Love Sour Spirit ®9003 The diarrhea control effect was significantly superior to 0.3% Benzoic acid raw powder, with no difference in growth performance, verified its “ Cost reduction and efficiency improvement ” The core advantage.

Direct viral inactivation: Experiments show that, C8、C10、C12 The combination can reduce ASFV Activity reaches 98%， GML Add to feed 1% This can reduce the viral load. 88%。

In PEDV In the challenge test, tiamulin (containing MCFA The intestinal viral load in piglets was significantly reduced, pathological damage was markedly alleviated, and the mortality rate was significantly decreased.

For a long time, Guangdong nuacid Bio Company NIC The R&D team maintains in-depth industry–university–research collaborations with numerous top-tier institutions, including Professor Xu Zhiwen’s team from the College of Veterinary Medicine at Sichuan Agricultural University, Professor He Jun’s team from the Institute of Animal Nutrition, Associate Professor Zou Tiande’s team from Jiangxi Agricultural University, and Professor Zhang Huihua’s team from the College of Animal Science and Technology at Foshan University, among others. By leveraging molecular docking technology and patented sustained-release processes (such as " Cold-Spray Coating Feed Acidifier Production Line " ) and other innovative technologies have enabled rapid translation from theory to application; this award is merely a microcosm of nuacid Bio’s journey of innovation. Moving forward, the company will continue to deepen research into the precise application of acidifying agents and expand their value in areas such as gut microbiota regulation and immune enhancement. Through promotion “ Acidic water, acidic environment, acidic feed ” plans, promote “ Comprehensive Reduction of Antibiotics in Aquaculture / Comprehensive Replacement of Antibiotics in Feed ” Play a demonstrative role across the entire industry value chain.

Written by: E Xiaodi

Review: Hu Youjun