Acid preparations reduce viral diarrhea, sparking another wave of discussion on the Weiwei Forum.

2025 year 6 month 5 day -6 On [date], the third Weiwei Forum grandly opened at the Huaju Junyue Hotel in Huadu, Guangzhou. Initiated by Dr. Yue Longyao, founder of Weiwei Nutrition, and co-organized by Guangdong nuacid and several other entities, the forum brought together technical leaders from leading global companies—including Muyuan, Wens, New Hope, Haida, Hefeng, Yangxiang, Cargill, and Anyou—as well as experts from China Agricultural University, Sichuan Agricultural University, Guangdong Academy of Agricultural Sciences, Huazhong Agricultural University, South China Agricultural University, Hunan Agricultural University, and Qingdao Agricultural University. Together, they focused on a core challenge facing the livestock and feed industries: the deep integration of precision nutrition and healthy farming. The event was further elevated by the presence of prominent figures from academia and industry; Researcher Jiang Zongyong, the principal author of China’s nutritional requirements for lean-type pigs, offered on-site guidance, while Professor Che Lianqiang, director of the Nutrition Research Institute at Sichuan Agricultural University—a national key discipline in animal nutrition—presided over the proceedings, generating significant anticipation for the conference.

Following 2024 Annual acid capacity NIC After Chief Scientist Researcher Hu Youjun gave a comprehensive presentation on “Lewis Acid–Base Electronic Theory Driving the Bacteriostatic and Antiviral Effects of Acid Preparations” at the Second Weiwei Forum, 2025 This year, in collaboration with Professor Xu Zhiwen’s team at the Animal Biotechnology Center of Sichuan Agricultural University, we are further exploring cutting-edge applications of this technology in sow health, strengthening the intestinal barrier in piglets, and controlling viral load. At a time when the swine farming industry faces dual pressures from rising feed costs and disease prevention challenges, Professor Xu Zhiwen’s team has innovatively introduced " Precision Nutrition - Disease prevention and control " Dual‑pronged approach to enhance efficiency. Professor Xu Zhiwen provides an in-depth analysis from a veterinary perspective: against the backdrop of routine ASF prevention and control, PEDV (Porcine epidemic diarrhea virus), PRRSV (Porcine Reproductive and Respiratory Syndrome Virus), SVV (Seneca Valley virus) and PRV New epidemiological characteristics of the four major diseases, including pseudorabies virus, and trends in mixed infections, based on the latest research findings on the antiviral mechanisms of novel acidifiers. The following outlines the main points of Professor Xu’s insightful presentation.

As a major global producer of swine, China has a large base of large-scale farms with high stocking densities. Coupled with increasingly complex farming environments and inadequate biosecurity systems, the epidemiology of swine diseases in China exhibits significant complexity, making disease control and eradication particularly challenging. This is mainly reflected in three key aspects: remarkable diversity in pathogen lineages, frequent strain mutation and recombination, and the continuous emergence of novel diseases—collectively posing multifaceted challenges to disease prevention and control. As Professor Xu’s report presented at the conference indicated, recently… 4 year PEDV The predominant circulating strains are BJ-2011(32.65%) Primarily, secondly AJ1102(20.4%) , and the strain exhibits significant mutation and recombination, 2025 The number of porcine epidemic diarrhea cases in the first quarter increased year on year. 58.44% ！

Although a stringent biosecurity system—including vaccination, environmental disinfection, and quarantine measures—has been implemented and has achieved some success in eradicating specific viruses, Professor Xu explicitly pointed out in his report that the current disease prevention and control framework still suffers from significant technical shortcomings: biological control measures are difficult to enforce comprehensively; effective vaccines remain unavailable for certain viruses; some immunized pigs exhibit poor immune responses, limiting vaccine efficacy; and certain pathogens mutate extensively, leaving existing vaccines unable to provide full protection. In light of these critical bottlenecks, Professor Xu innovatively proposed approaches starting from... Breaking Through Pandemic Challenges Through Functional Nutritional Regulation 。 

Research shows that, MCTS It exhibits significant antiviral effects and exerts favorable regulatory and control actions on animal physiology and pathogens. Joshua Wait ( 2020 ) Studies have confirmed that a combination of caprylic, capric, and lauric acids—medium-chain fatty acids—and lauric acid monoglyceride effectively inactivate African swine fever virus in feed and drinking water.

NIC Based on Lewis acid–base electronic theory and using molecular docking techniques, models were established for medium-chain fatty acids and monoglycerides, including lauric acid and its monoglyceride, as well as active flavonoids and PEDV 、 PRRSV A kinetic model of the response to viral structural protein targets was developed, and computer-based molecular simulations were used to preliminarily screen for the optimal antiviral efficacy combination.

The study first established full-process validation of antiviral activity through cell safety assays, cellular efficacy tests, and verification of in vivo antiviral effects in animal challenge models. Additionally, cell-based experiments demonstrated that the antiviral acid exhibits… PRRSV 、 PEDV 、 SVV and PRV The viral inhibition rate reaches 75%-90%

Inoculate a certain dose into the creep feed. PEDV , add separately 0、0.25、0.5、1.0、2.0g/kg Antiviral acid, and store 7 Heaven, testing the viral load in feed, the results showed that as storage time increased, the viral load in the feed... PEDV Viral load decreased in a dose-dependent manner, indicating that adding antiviral acid to creep feed can significantly reduce the viral load in the feed.

Professor Xu’s experiments show that, 7 Day-old piglets PEDV Typical symptoms such as vomiting and diarrhea appeared rapidly after viral challenge. In the low-dose antiviral group, symptoms were similar to those in the model group but did not progress to failure; recovery occurred gradually in the later stages. No vomiting was observed in the medium- and high-dose groups, and in the high-dose group, only some piglets exhibited transient diarrhea that resolved quickly. Pathological examination revealed that, PEDV The primary damage affected the jejunum and ileum, leading to villous atrophy, shedding, and an inflammatory response; however, in the antiviral acid-treated group, intestinal injury was significantly alleviated, demonstrating a favorable antiviral effect. Serum biochemistry revealed that, PEDV Serum immunoglobulin levels were reduced, whereas the antiviral acid-treated group showed improved elevation of serum immunoglobulin levels, thereby enhancing the host’s immune function.

The experimental results show that taic acid can effectively inhibit PRRSV Replication in piglets reduces viral load and pathological damage in lung tissue and mediastinal lymph nodes, decreasing PRRSV Reduce mortality after challenge, shorten the virus shedding period following challenge, alleviate high fever and elevated body temperature in piglets, and improve PRRSV The reduction in body weight following viral challenge promotes rapid recovery of growth performance in animals.

The results showed that in the control group, the alveolar structure was clear with no obvious lesions; the spleen, kidneys, and liver all exhibited clear structures with no significant abnormalities. Piglets were challenged with the pathogen. SVV Subsequently, the virus-challenged group exhibited localized pulmonary atrophy and thickening of the alveolar septa, with compensatory emphysema in the remaining lung tissue. The spleen showed diffuse hemorrhage. Glomerular atrophy was observed, along with partial shedding of renal tubular epithelium. In the taurine group, some lung tissue displayed atrophy and compensatory emphysema; no obvious lesions were seen in the spleen, and mild dilation of renal tubules was noted. Stem cells were severely swollen, with focal cellular necrosis.

The research findings revealed: mice were challenged with the pathogen. PRV Subsequently, in the virus-challenged group, severe hemorrhage and parenchymal lesions were observed in lung tissue after viral challenge, with meningeal hemorrhage evident. Histopathological examination revealed lymphocytic infiltration of cerebral blood vessels forming a “cuffing” pattern, marked thickening of alveolar walls, and inflammatory infiltrate. In contrast, administration of an antiviral agent resulted in a significant reduction in viral loads in both the lungs and brain, marked alleviation of meningeal hemorrhage, restoration of alveolar wall architecture, and attenuation of the inflammatory response.

Currently, the Acid Innovation Center and the Animal Biotechnology Innovation Center of Sichuan Agricultural University are working closely together, in PEDV Further progress has been made in research on PRRS and the clearance of the virus, and we look forward to providing more practical nutritional and health‑management solutions for the healthy rearing of piglets! Centered on practical insights and real-world applicability, this forum delivered a feast of ideas and technology to the industry. Research by nuacid Bio in collaboration with Professor Xu Zhiwen’s team at Sichuan Agricultural University has underscored that healthy livestock production hinges on nutritional management, while disease prevention and control demand multidisciplinary integration. Looking ahead, let us join forces—using precision nutrition as our spear and innovative technologies as our shield—to dispel the “dark clouds” over sustainable farming and usher in a bright future for the industry’s enduring growth.

Though the road to breaking the deadlock is long, perseverance will lead us there; though the future ahead is fraught with challenges, determination will ensure our success!

Written by: E Xiaodi

Review: Hu Youjun